Buy 3-FA Powder Online | High-Purity Substituted Amphetamine Research Chemical

Introduction to Buy 3-FA Powder

Buy 3-FA Powder (3-Fluoroamphetamine), designated in pharmacological literature as a novel synthetic substituted amphetamine, is a highly potent research chemical and a critical reference standard in neuropharmacological and forensic research. Structurally, it is the 3-fluoro analog of amphetamine, featuring a fluorine atom at the 3-position of the phenyl ring, while retaining the characteristic primary aminoalkyl side chain.

In neuropharmacological research, the positional isomerism of halogenated amphetamines is a paramount variable that dictates monoamine transporter selectivity. While 4-FA exhibits significant serotonin releasing agent (SRA) activity alongside catecholaminergic efficacy (an entactogen-stimulant profile), and 2-FA operates almost exclusively as a functional dopamine/norepinephrine releasing agent (DNRI), 3-FA occupies a distinct intermediate niche. 3-FA functions as a potent dopamine and norepinephrine releasing agent (DNRA) with highly selective catecholaminergic efficacy and only marginal serotonergic activity. This makes it an essential “functional stimulant” reference standard for isolating pure dopaminergic and noradrenergic signaling in vitro. Furthermore, the 3-fluoro group provides “metabolic shielding” by blocking hepatic 3-hydroxylation—a primary metabolic pathway for non-halogenated amphetamine—drastically increasing the molecule’s lipophilicity and metabolic stability. Supplied as a stable hydrochloride (HCl) crystalline powder, this format offers exceptional versatility for laboratories requiring custom volumetric dosing for in-vitro assay preparation and analytical calibration. Note: This product is strictly intended for in-vitro research and analytical purposes only.

Key Features and Benefits – Buy 3-FA Powder

• Raw Powder Versatility: Supplied as a pure, crystalline powder, this format allows researchers to create precise, custom-concentration volumetric solutions tailored to unique in-vitro assay requirements, eliminating the variables of pre-mixed liquids or fixed-dose units.
• Positional Isomer SAR Mapping: 3-FA provides researchers with the essential 3-fluoro analog required for comparative structural-activity relationship (SAR) studies against 2-FA and 4-FA, mapping how the position of the fluorine atom dictates the SERT/DAT/NET selectivity gradient.
• Functional Stimulant Profiling: Due to its minimal SERT efficacy, 3-FA is a premier reference standard for modeling pure dopaminergic and noradrenergic release and reuptake inhibition in vitro, allowing researchers to isolate these pathways without serotonergic confounding variables.
• 3-Fluoro Metabolic Shielding: The 3-fluoro group blocks primary aromatic 3-hydroxylation, drastically extending metabolic stability and altering bioavailability compared to non-halogenated amphetamine, making it essential for comparative metabolic studies.
• Primary Amine Kinetics: As a primary amine (lacking the N-methyl group of 3-FMA), 3-FA provides a vital baseline for studying how N-demethylation kinetics and primary vs. secondary amine status affect monoamine transporter interaction and hepatic clearance.
• Analytical Standard: Essential for forensic and analytical laboratories requiring pure reference materials to validate LC/MS and GC/MS instruments and detect emerging fluorinated amphetamine NPS in biological matrices.

Product Specifications

• Chemical Name: 1-(3-fluorophenyl)propan-2-amine hydrochloride
• Common Designation: 3-FA / 3-Fluoroamphetamine
• CAS Number: 5680-79-5 (HCl)
• Class: Substituted Amphetamine / Halogenated Phenethylamine / DNRI / Research Chemical
• Form: Crystalline Powder (Hydrochloride Salt)
• Purity: ≥ 98% (Verified by Independent Third-Party Testing)
• Appearance: White to off-white fine crystalline powder
• Storage Requirements: Store in a cool, dry, dark environment (ideally -20°C for long-term archival). Keep container tightly sealed under inert gas to prevent hygroscopic absorption and oxidation.
• Solubility: Freely soluble in water, DMSO, and ethanol.

Applications and Usage

3-FA Powder is exclusively designated for in-vitro (outside a living organism) research and analytical applications. Common laboratory applications include:

• Monoamine Transporter Assays: Investigating the compound’s high affinity and efficacy as a dopamine and norepinephrine releasing agent using isolated synaptosomal preparations, and contrasting its SERT/DAT/NET selectivity profile against 2-FA, 4-FA, and d-amphetamine.
• Positional Isomer SAR Studies: Contrasting the pharmacokinetic properties and receptor conformational changes induced by 3-fluoro substitution (3-FA) versus 2-fluoro (2-FA) and 4-fluoro (4-FA) to map the steric and electronic limits of the transporter binding pockets.
• Metabolic Pathway Studies: Analyzing the hepatic breakdown of 3-fluoro primary amphetamines using hepatocyte cultures and liver microsomes, specifically quantifying the blockage of 3-hydroxylation and the shift to alternative oxidative deamination pathways.
• Forensic and Analytical Calibration: Utilizing 3-FA as a certified reference material (CRM) for GC/MS, LC/MS, and NMR spectroscopy to validate analytical instruments and detect 3-FA and its unique biomarkers in biological matrices.

Disclaimer: This product is not for human or veterinary consumption. It must only be handled in controlled laboratory environments by qualified professionals.

Purity and Testing

We guarantee a purity level of ≥ 98% for our 3-FA Powder. Every batch undergoes rigorous, independent third-party testing to verify chemical identity, absolute purity, and the absence of dangerous residual solvents, heavy metals, or unreacted precursors. Because substituted amphetamines are a heavily counterfeited class, we perform exhaustive screening to ensure the absolute absence of dangerous contaminants (such as amphetamine, methamphetamine, 4-FA, 2-FA, or synthetic opioids). Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are provided upon request.

Safety and Handling

WARNING: 3-FA IS A HIGHLY POTENT CENTRAL NERVOUS SYSTEM STIMULANT AND DOPAMINE RELEASING AGENT. EXTREME CAUTION IS REQUIRED.

• Personal Protective Equipment (PPE): Always wear appropriately sized nitrile gloves, chemical-resistant safety goggles, and an N95 or P100 particulate respirator when weighing or transferring the powder.
• Ventilation: Handling must only occur within a certified chemical fume hood to prevent the inhalation of aerosolized particles.
• Accidental Exposure: In the event of skin contact, wash the area thoroughly with soap and water. For eye contact, flush with copious amounts of water for at least 15 minutes.
• Hygiene: Remove contaminated clothing immediately and wash hands thoroughly after handling, even when PPE is utilized.
• Secure Storage: Keep powder locked away in a secure, access-controlled laboratory cabinet, out of reach of unauthorized personnel.

Global Shipping and Discreet Delivery

• Global Reach: We ship 3-FA Powder internationally, in strict compliance with international shipping regulations.
• Discreet Packaging: All orders are dispatched in unmarked, tamper-evident, and odor-proof packaging. The outer packaging does not indicate the nature of the contents.
• Rapid Processing: Orders are processed and shipped within 24 hours of cleared payment. We offer standard and express courier options with full end-to-end tracking.
• Secure Handling: Powders are double-sealed in moisture-barrier bags and placed within sturdy outer containers to prevent damage during transit.

Why Choose Us To Buy 3-FA Powder?

• Uncompromising Quality: We work directly with top-tier chemical synthesis laboratories and verify every batch in-house and via third-party labs before it reaches you.
• Total Transparency: We provide full analytical data. What is on the label is exactly what is in the bag—no fillers, no impurities, no compromises.
• Expert Customer Support: Our support team understands the nuances of research chemicals and is ready to assist with CoA requests, shipping inquiries, and technical questions.
• Secure Transactions: We utilize SSL encryption and accept secure, discreet payment methods, including major cryptocurrencies (Bitcoin, Monero, Ethereum) and secure bank transfers.

Legal and Safety Compliance

3-FA Powder is sold strictly as a research chemical and is not approved by the FDA, EMA, or any equivalent regulatory body for human or veterinary use.

It is the sole responsibility of the purchaser to ensure that the acquisition, possession, and use of 3-Fluoroamphetamine comply with all local, state, national, and international laws. Warning: 3-FA is a potent central nervous system stimulant and catecholamine releasing agent. Ingestion can cause severe, life-threatening psychological and physiological effects, including severe tachycardia, hypertension, hyperthermia, and severe psychological distress. As a direct analog of amphetamine (a Schedule II controlled substance in many jurisdictions), it frequently falls under federal analogue acts or specific NPS legislation globally. We do not ship to regions where this compound is explicitly prohibited. By purchasing from us, you affirm that you are a qualified researcher or institutional buyer over the age of 18, and you assume all legal liability for the product upon delivery.

Frequently Asked Questions (FAQ)

Q1: What is 3-FA?
A: 3-FA (3-Fluoroamphetamine) is a novel synthetic substituted amphetamine. It is the 3-fluoro analog of amphetamine. It acts primarily as a potent dopamine and norepinephrine releasing agent (DNRI), promoting the release and inhibiting the reuptake of catecholamines in vitro.

Q2: What makes 3-FA different from Amphetamine?
A: The primary difference is the 3-fluoro group on the phenyl ring. In amphetamine, the liver rapidly converts the molecule into 3-hydroxyamphetamine. The 3-fluoro group in 3-FA blocks this metabolic pathway (metabolic shielding), drastically increasing its metabolic stability and lipophilicity. Additionally, the 3-fluoro substitution subtly alters transporter selectivity.

Q3: What makes 3-FA different from 2-FA and 4-FA?
A: The position of the fluorine atom dictates the pharmacological profile. 4-FA is a mixed DNRI/SRA (entactogen-stimulant). 2-FA is a highly selective functional DNRI. 3-FA occupies an intermediate niche: it is predominantly a functional catecholaminergic releaser like 2-FA, but possesses a slightly more pronounced (though still secondary) serotonergic push, making it essential for mapping the positional isomer SAR gradient.

Q4: What makes 3-FA different from 3-FMA?
A: 3-FA is a primary amine (like amphetamine), while 3-FMA is a secondary amine (N-methylated, like methamphetamine). This difference affects lipophilicity, blood-brain barrier penetration, and primary metabolic pathways (3-FA undergoes oxidative deamination, while 3-FMA primarily undergoes N-demethylation). 3-FA provides a vital baseline for studying primary vs. secondary amine kinetics in vitro.

Q5: Can 3-FA Powder be consumed?
A: Absolutely not. 3-FA is a potent CNS stimulant and DNRI. It is sold strictly for in-vitro laboratory and analytical research. Ingestion can cause unpredictable, severe psychological and cardiovascular effects and is strictly prohibited.

Q6: Do you provide a Certificate of Analysis (CoA)?
A: Yes. We provide a comprehensive CoA—including HPLC, GC/MS, and NMR data—for every batch we sell. This guarantees the identity, purity, and mass of the compound.

Q7: Is it legal to buy 3-FA in my country?
A: Legality varies drastically by country and is subject to change. Because it is a direct structural analog of amphetamine, it is often controlled under analogue acts or specific NPS bans. We cannot provide legal advice. It is your responsibility to research your local laws regarding this compound before placing an order.

Q8: How should I store 3-FA Powder for long-term research?
A: For maximum longevity, store 3-FA powder in an airtight, amber glass vial under an inert gas (like Argon) in a freezer set to -20°C. Keep away from direct sunlight, heat, and moisture.