Buy 5-APB Powder Online | High-Purity Substituted Benzofuran Research Chemical

Introduction to Buy 5-APB Powder

Buy 5-APB Powder (5-(2-aminopropyl)benzofuran), commonly designated as 5-APB or historically by the designation “Benzofury”, is a highly potent, novel synthetic substituted benzofuran and a critical reference standard in neuropharmacological and forensic research. Structurally, it is the 5-positional isomer of 6-APB and a direct ring-substituted analog of MDA (3,4-methylenedioxyamphetamine), featuring a primary amine group at the nitrogen tail.

In neuropharmacological research, 5-APB operates as a potent monoamine releasing agent (MRA) and reuptake inhibitor, exhibiting strong efficacy at the serotonin transporter (SERT), with notable activity at dopamine (DAT) and norepinephrine (NET) transporters. Because it features a primary amine (NH2) rather than the N-methyl group of 5-MAPB, it provides a vital reference point for studying the structural-activity relationships (SAR) of N-alkylation on benzofuran neurochemistry. A well-known challenge with 5-APB is that the freebase form is a notoriously unstable, hygroscopic oil that is virtually impossible to accurately weigh. To solve this, our 5-APB is supplied as a stable crystalline hydrochloride (HCl) powder. This format ensures exceptional physical stability, precise measurability, and safe handling for advanced laboratory environments. Note: This product is strictly intended for in-vitro research and analytical purposes only.

Key Features and Benefits – Buy 5-APB Powder

• Crystalline Stability: The HCl salt crystalline structure prevents the compound from melting into an unmanageable, viscous oil at room temperature—a notorious issue with freebase benzofurans—ensuring accurate, reproducible micro-weighing.
• Primary Amine SAR Mapping: As the direct analog of MDA, 5-APB allows researchers to study how the removal of the methylenedioxy ring and the addition of the benzofuran oxygen affects pharmacokinetics, and how the primary amine (5-APB) compares to the secondary N-methyl amine (5-MAPB) at monoamine transporters.
• Positional Isomer Profiling: Essential for comparative structural-activity relationship (SAR) studies against 6-APB, allowing researchers to quantify how the position of the aminopropyl chain (5- vs. 6-position) dictates SERT/DAT selectivity.
• Raw Powder Versatility: Supplied as a pure, crystalline powder, this format allows researchers to create precise, custom-concentration volumetric solutions tailored to unique in-vitro assay requirements.
• Aqueous Solubility: As a stable HCl salt, the crystal powder dissolves readily in water and buffers, streamlining assay preparation.

Product Specifications

• Chemical Name: 1-(1-benzofuran-5-yl)propan-2-amine hydrochloride
• Common Designation: 5-APB / 5-(2-aminopropyl)benzofuran
• CAS Number: 2868-37-3 (Refer to CoA for specific salt form)
• Class: Substituted Benzofuran / Entactogen / Monoamine Releasing Agent / Research Chemical
• Form: Crystalline Powder (Hydrochloride Salt)
• Purity: ≥ 98% (Verified by Independent Third-Party Testing)
• Appearance: White to off-white fine crystalline powder
• Storage Requirements: Store in a cool, dry, dark environment (ideally -20°C for long-term archival). Keep container tightly sealed under inert gas to prevent hygroscopic absorption and oxidation.
• Solubility: Freely soluble in water, DMSO, and ethanol.

Applications and Usage

5-APB Powder is exclusively designated for in-vitro (outside a living organism) research and analytical applications. Common laboratory applications include:

• Monoamine Transporter Assays: Investigating the compound’s efficacy as a serotonin, dopamine, and norepinephrine releasing agent using isolated synaptosomal preparations, and contrasting its releasing vs. reuptake inhibition profile.
• N-Alkyl Substitution SAR Studies: Mapping how the primary amine of 5-APB alters receptor binding and transporter kinetics compared to the N-methyl secondary amine of 5-MAPB, modeling the MDA-to-MDMA structural transition in the benzofuran class.
• Positional Isomer SAR Studies: Contrasting the pharmacokinetic properties and receptor conformational changes induced by 5-substitution (5-APB) versus 6-substitution (6-APB) to map the spatial limits of the SERT and DAT binding pockets.
• Metabolic Pathway Studies: Analyzing the hepatic breakdown, deamination, and oxidative metabolism of primary-amine benzofurans using hepatocyte cultures and liver microsomes.
• Forensic and Analytical Calibration: Utilizing 5-APB as a certified reference material (CRM) for GC/MS, LC/MS, and NMR spectroscopy to validate analytical instruments and detect emerging benzofuran NPS in biological matrices.

Disclaimer: This product is not for human or veterinary consumption. It must only be handled in controlled laboratory environments by qualified professionals.

Purity and Testing

We guarantee a purity level of ≥ 98% for our 5-APB Powder. Every batch undergoes rigorous, independent third-party testing to verify chemical identity, absolute purity, and the absence of dangerous residual solvents, heavy metals, or unreacted precursors. Crucially, we perform rigorous isomeric profiling to ensure the absolute absence of the 6-APB isomer—a vital verification for accurate positional SAR research and forensic calibration. Because substituted benzofurans are prone to oxidative degradation, special analytical care is taken to ensure minimal presence of degradation products. Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are provided upon request.

Safety and Handling

WARNING: 5-APB IS A HIGHLY POTENT CENTRAL NERVOUS SYSTEM STIMULANT AND ENTACTOGEN. EXTREME CAUTION IS REQUIRED.

• Personal Protective Equipment (PPE): Always wear appropriately sized nitrile gloves, chemical-resistant safety goggles, and an N95 or P100 particulate respirator when weighing or transferring the powder.
• Ventilation: Handling must only occur within a certified chemical fume hood to prevent the inhalation of aerosolized particles.
• Accidental Exposure: In the event of skin contact, wash the area thoroughly with soap and water. For eye contact, flush with copious amounts of water for at least 15 minutes.
• Hygiene: Remove contaminated clothing immediately and wash hands thoroughly after handling, even when PPE is utilized.

Global Shipping and Discreet Delivery

• Global Reach: We ship 5-APB Powder internationally, in strict compliance with international shipping regulations.
• Discreet Packaging: All orders are dispatched in unmarked, tamper-evident, and odor-proof packaging. The outer packaging does not indicate the nature of the contents.
• Rapid Processing: Orders are processed and shipped within 24 hours of cleared payment. We offer standard and express courier options with full end-to-end tracking.
• Secure Handling: Powders are double-sealed in moisture-barrier bags and placed within sturdy outer containers to prevent damage during transit.

Why Choose Us To Buy 5-APB Powder?

• Uncompromising Quality: We work directly with top-tier chemical synthesis laboratories and verify every batch in-house and via third-party labs before it reaches you.
• Total Transparency: We provide full analytical data. What is on the label is exactly what is in the bag—no fillers, no impurities, no compromises.
• Expert Customer Support: Our support team understands the nuances of research chemicals and is ready to assist with CoA requests, shipping inquiries, and technical questions.
• Secure Transactions: We utilize SSL encryption and accept secure, discreet payment methods, including major cryptocurrencies (Bitcoin, Monero, Ethereum) and secure bank transfers.

Legal and Safety Compliance

5-APB Powder is sold strictly as a research chemical and is not approved by the FDA, EMA, or any equivalent regulatory body for human or veterinary use.

It is the sole responsibility of the purchaser to ensure that the acquisition, possession, and use of 5-APB comply with all local, state, national, and international laws. Warning: 5-APB is a potent central nervous system stimulant and monoamine releasing agent. Ingestion can cause severe, life-threatening cardiovascular events, hyperthermia, acute serotonin syndrome, and neurotoxicity. It may fall under federal analogue acts or specific substituted benzofuran/NPS legislation in various jurisdictions. We do not ship to regions where this compound is explicitly prohibited. By purchasing from us, you affirm that you are a qualified researcher or institutional buyer over the age of 18, and you assume all legal liability for the product upon delivery.

Frequently Asked Questions (FAQ)

Q1: What is 5-APB?
A: 5-APB (5-(2-aminopropyl)benzofuran) is a synthetic substituted benzofuran. It features a primary amine group, making it the direct benzofuran analog of MDA. It acts primarily as a potent monoamine releasing agent (MRA), strongly promoting the release of serotonin, dopamine, and norepinephrine in vitro.

Q2: What makes 5-APB different from 5-MAPB?
A: The difference lies in the amine tail. 5-APB has a primary amine (NH2), while 5-MAPB has a secondary N-methyl amine (N-CH3). This structural difference mirrors the MDA-to-MDMA transition, allowing researchers to study how N-alkylation affects SERT/DAT selectivity, metabolic stability, and neurochemical release profiles in the benzofuran class.

Q3: What makes 5-APB different from 6-APB?
A: Both are positional isomers, meaning the aminopropyl chain is attached to a different carbon on the benzofuran ring (5-position vs. 6-position). This spatial difference alters how the molecule docks into the monoamine transporters (SERT/DAT), resulting in distinct releasing profiles and making both essential for comparative positional-isomer SAR research.

Q4: Why choose the crystalline HCl powder form over freebase?
A: Freebase substituted benzofurans are notoriously unstable, often melting into an unmanageable, sticky oil at room temperature, making accurate weighing impossible. The crystalline HCl powder form is stable, solid, and dry, allowing for precise micro-weighing and reproducible assay preparation.

Q5: Can 5-APB Powder be consumed?
A: Absolutely not. 5-APB is a potent CNS stimulant and monoamine releasing agent. It is sold strictly for in-vitro laboratory and analytical research. Ingestion can cause unpredictable, severe cardiovascular and psychological effects, including serotonin syndrome, and is strictly prohibited.

Q6: Do you provide a Certificate of Analysis (CoA)?
A: Yes. We provide a comprehensive CoA—including HPLC, GC/MS, isomeric profiling, and NMR data—for every batch we sell. This guarantees the identity, purity, and mass of the compound.

Q7: Is it legal to buy 5-APB in my country?
A: Legality varies drastically by country and is subject to change. Because it is structurally related to MDA and other scheduled amphetamines/benzofurans, it is often controlled under analogue acts or specific NPS bans. We cannot provide legal advice. It is your responsibility to research your local laws regarding this compound before placing an order.

Q8: How should I store 5-APB Powder for long-term research?
A: For maximum longevity, store 5-APB powder in an airtight, amber glass vial under an inert gas (like Argon) in a freezer set to -20°C. Keep away from direct sunlight, heat, and moisture.